Sabin Vaccine in Poliomyelitis Eradication: Achievements and Risks

[History of development of the live poliomyelitis vaccine from Sabin attenuated strains in 1959 and idea of poliomyelitis eradication].

In 1958 Poliomyelitis Institute in Moscow and Institute of Experimental Medicine in St. Petersburg received from A. Sabin the attenuated strains of poliomyelitis virus. The characteristics of the strains were thoroughly studied by A. A. Smorodintsev and coworkers. They found that the virulence of the strains fluctuated slightly in 10 consecutive passages through the intestine of the non-immune ...

[Paralitic poliomyelitis caused by the oral Sabin vaccine: time for a vaccine change?].

España tiene un sistema nacional de salud descentralizado con larga tradición en atención primaria y es un pilar del estado de bienestar, por lo que la medicina pública es la primera opción de todo médico especializado y, en particular, para los egresados de medicina familiar. El orientarse a la medicina privada es una opción que está más relacionada con retornar a su país o migrar a otro, que ...

Poliomyelitis Vaccine

The Epidemiology of poliomgelitis has been investigated in our country Pasteur Institute; the incidence of Poliomgelitis, after the age of 4 years i's rare, in Iran.  Passive antibody of maternal origin do not interfere with production of active antibody after immunization.  Inactivated Polio Vaccine (salk) has been effective in reducing the incidence of poliomge­litis by approximately 90 per ...

A Cluster of Paralytic Poliomyelitis Cases Due to Transmission of Slightly Diverged Sabin 2 Vaccine Poliovirus.

UNLABELLED Four cases of acute flaccid paralysis caused by slightly evolved (Sabin-like) vaccine polioviruses of serotype 2 were registered in July to August 2010 in an orphanage of Biysk (Altai Region, Russia). The Biysk cluster of vaccine-associated paralytic poliomyelitis (VAPP) had several uncommon, if not unique, features. (i) Until this outbreak, Sabin-like viruses (in distinction to more...

poliomyelitis eradication in iran: opportunities and challenges